HuR stabilizes lnc-Sox5 mRNA to promote tongue carcinogenesis
- 作者: Wang L.1,2, Ye S.2, Wang J.2, Gu Z.2, Zhang Y.2, Zhang C.2, Ma X.2
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隶属关系:
- Qingdao University
- Department of Oncology
- 期: 卷 82, 编号 4 (2017)
- 页面: 438-445
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151331
- DOI: https://doi.org/10.1134/S0006297917040046
- ID: 151331
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详细
Long noncoding RNAs (lncRNAs) have been recently regarded as systemic regulators in multiple biological processes including tumorigenesis. In this study, we report an ultra-highly expressed lncRNA, lnc-Sox5, in tongue tumor tissues. The results imply that lnc-Sox5 may play vital role in tongue carcinoma progression. We observed that the growth of Tca8113 cells was suppressed by lnc-Sox5 downregulation. Additionally, lnc-Sox5 knockdown simultaneously increased Tca8113 cell apoptosis, but the cell cycle was arrested. RNA immunoprecipitation suggested that HuR directly bound to and stabilized lnc-Sox5 RNA. Consistently, HuR knockdown reduced the level of lnc-Sox5 in Tca8113 cells. However, overexpression of HuR induced more lnc-Sox5 in Tca8113 cells. Both lnc-Sox5 knockdown and HuR knockdown suppressed Tca8113 cell tumorigenesis in xenograft models. These results suggest that lnc-Sox5, which was stabilized by HuR, could regulate carcinogenesis of tongue cancer and may serve as a predicted target for tongue carcinoma therapies.
作者简介
Lifang Wang
Qingdao University; Department of Oncology
Email: maxuezhen1978@hotmail.com
中国, 266000, Qingdao; Shandong
Shucheng Ye
Department of Oncology
Email: maxuezhen1978@hotmail.com
中国, Shandong
Junye Wang
Department of Oncology
Email: maxuezhen1978@hotmail.com
中国, Shandong
Zhenfang Gu
Department of Oncology
Email: maxuezhen1978@hotmail.com
中国, Shandong
Yanhui Zhang
Department of Oncology
Email: maxuezhen1978@hotmail.com
中国, Shandong
Chunmei Zhang
Department of Oncology
Email: maxuezhen1978@hotmail.com
中国, Shandong
Xuezhen Ma
Department of Oncology
编辑信件的主要联系方式.
Email: maxuezhen1978@hotmail.com
中国, Qingdao, Shandong