Mechanisms of long-term plasticity of hippocampal GABAergic synapses
- 作者: Bolshakov A.1,2, Rozov A.3,4, Valiullina F.3
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隶属关系:
- Institute of Higher Nervous Activity and Neurophysiology
- Russian National Research Medical University
- Kazan Federal University
- Division of Neuro- and Sensory Physiology, Institute of Physiology and Pathophysiology
- 期: 卷 82, 编号 3 (2017)
- 页面: 257-263
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151277
- DOI: https://doi.org/10.1134/S0006297917030038
- ID: 151277
如何引用文章
详细
Long-term potentiation and depression of synaptic transmission have been considered as cellular mechanisms of memory in studies conducted in recent decades. These studies were predominantly focused on mechanisms underlying plasticity at excitatory synapses. Nevertheless, normal central nervous system functioning requires maintenance of a balance between inhibition and excitation, suggesting existence of similar modulation of glutamatergic and GABAergic synapses. Here we review the involvement of G-protein-coupled receptors in the generation of long-term changes in synaptic transmission of inhibitory synapses. We considered the role of endocannabinoid and glutamate systems, GABAB and opioid receptors in the induction of long-term potentiation and long-term depression in inhibitory synapses. The preand postsynaptic effects of activation of these receptors are also discussed.
作者简介
A. Bolshakov
Institute of Higher Nervous Activity and Neurophysiology; Russian National Research Medical University
编辑信件的主要联系方式.
Email: al230679@yandex.ru
俄罗斯联邦, Moscow, 117485; Moscow, 117997
A. Rozov
Kazan Federal University; Division of Neuro- and Sensory Physiology, Institute of Physiology and Pathophysiology
Email: al230679@yandex.ru
俄罗斯联邦, Kazan, 420008; Heidelberg, 69120
F. Valiullina
Kazan Federal University
Email: al230679@yandex.ru
俄罗斯联邦, Kazan, 420008
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