Localization of nuclear-encoded mRNAs to mitochondria outer surface
- 作者: Golani-Armon A.1,2, Arava Y.1
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隶属关系:
- Faculty of Biology
- Nanotechnology and Nanoscience Program
- 期: 卷 81, 编号 10 (2016)
- 页面: 1038-1043
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151021
- DOI: https://doi.org/10.1134/S0006297916100023
- ID: 151021
如何引用文章
详细
The diverse functions of mitochondria depend on hundreds of different proteins. The vast majority of these proteins is encoded in the nucleus, translated in the cytosol, and must be imported into the organelle. Import was shown to occur after complete synthesis of the protein, with the assistance of cytosolic chaperones that maintain it in an unfolded state and target it to the mitochondrial translocase of the outer membrane (TOM complex). Recent studies, however, identified many mRNAs encoding mitochondrial proteins near the outer membrane of mitochondria. Translation studies suggest that many of these mRNAs are translated locally, presumably allowing cotranslational import into mitochondria. Herein we review these data and discuss its relevance for local protein synthesis. We also suggest alternative roles for mRNA localization to mitochondria. Finally, we suggest future research directions, including revealing the significance of localization to mitochondria physiology and the molecular players that regulate it.
作者简介
A. Golani-Armon
Faculty of Biology; Nanotechnology and Nanoscience Program
Email: arava@tx.technion.ac.il
以色列, Haifa, 32000; Haifa, 32000
Y. Arava
Faculty of Biology
编辑信件的主要联系方式.
Email: arava@tx.technion.ac.il
以色列, Haifa, 32000
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