α-Tocopheryl succinate affects malignant cell viability, proliferation, and differentiation
- 作者: Savitskaya M.1, Onischenko G.1
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隶属关系:
- Faculty of Biology
- 期: 卷 81, 编号 8 (2016)
- 页面: 806-818
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150969
- DOI: https://doi.org/10.1134/S0006297916080034
- ID: 150969
如何引用文章
详细
The widespread occurrence of malignant tumors motivates great attention to finding and investigating effective new antitumor preparations. Such preparations include compounds of the vitamin E family. Among them, α-tocopheryl succinate (vitamin E succinate (VES)) has the most pronounced antitumor properties. In this review, various targets and mechanisms of the antitumor effect of vitamin E succinate are characterized. It has been shown that VES has multiple intracellular targets and effects, and as a result VES is able to induce apoptosis in tumor cells, inhibit their proliferation, induce differentiation, prevent metastasizing, and inhibit angiogenesis. However, VES has minimal effects on normal cells and tissues. Due to the variety of targets and selectivity of action, VES is a promising agent against malignant neoplasms. More detailed studies in this area can contribute to development of effective and safe chemotherapeutic preparations.
作者简介
M. Savitskaya
Faculty of Biology
编辑信件的主要联系方式.
Email: nakomis@mail.ru
俄罗斯联邦, Moscow, 119991
G. Onischenko
Faculty of Biology
Email: nakomis@mail.ru
俄罗斯联邦, Moscow, 119991
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