电邮这篇文章 mRNA-based therapeutics–Advances and perspectives
- 作者: Sergeeva O.1,2, Koteliansky V.1,2, Zatsepin T.1,2,3
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隶属关系:
- Department of Chemistry
- Skolkovo Innovation Center
- The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance
- 期: 卷 81, 编号 7 (2016)
- 页面: 709-722
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150939
- DOI: https://doi.org/10.1134/S0006297916070075
- ID: 150939
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详细
In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.
作者简介
O. Sergeeva
Department of Chemistry; Skolkovo Innovation Center
编辑信件的主要联系方式.
Email: olga.sergeeva.v@gmail.com
俄罗斯联邦, Moscow, 119991; 3 Nobel str., Moscow, 143026
V. Koteliansky
Department of Chemistry; Skolkovo Innovation Center
Email: olga.sergeeva.v@gmail.com
俄罗斯联邦, Moscow, 119991; 3 Nobel str., Moscow, 143026
T. Zatsepin
Department of Chemistry; Skolkovo Innovation Center; The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance
Email: olga.sergeeva.v@gmail.com
俄罗斯联邦, Moscow, 119991; 3 Nobel str., Moscow, 143026; Moscow, 111123
