Viral vectors for gene therapy: Current state and clinical perspectives
- 作者: Lukashev A.1,2, Zamyatnin A.3,4
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隶属关系:
- Chumakov Institute of Poliomyelitis and Viral Encephalitides
- Martsinovsky Institute of Medical Parasitology and Tropical Medicine
- Institute of Molecular Medicine
- Belozersky Institute of Physico-Chemical Biology
- 期: 卷 81, 编号 7 (2016)
- 页面: 700-708
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150938
- DOI: https://doi.org/10.1134/S0006297916070063
- ID: 150938
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详细
Gene therapy is the straightforward approach for the application of recent advances in molecular biology into clinical practice. One of the major obstacles in the development of gene therapy is the delivery of the effector to and into the target cell. Unfortunately, most methods commonly used in laboratory practice are poorly suited for clinical use. Viral vectors are one of the most promising methods for gene therapy delivery. Millions of years of evolution of viruses have resulted in the development of various molecular mechanisms for entry into cells, long-term survival within cells, and activation, inhibition, or modification of the host defense mechanisms at all levels. The relatively simple organization of viruses, small genome size, and evolutionary plasticity allow modifying them to create effective instruments for gene therapy approaches. This review summarizes the latest trends in the development of gene therapy, in particular, various aspects and prospects of the development of clinical products based on viral delivery systems.
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作者简介
A. Lukashev
Chumakov Institute of Poliomyelitis and Viral Encephalitides; Martsinovsky Institute of Medical Parasitology and Tropical Medicine
编辑信件的主要联系方式.
Email: alexander_lukashev@hotmail.com
俄罗斯联邦, Moscow, 142782; Moscow, 119991
A. Zamyatnin
Institute of Molecular Medicine; Belozersky Institute of Physico-Chemical Biology
Email: alexander_lukashev@hotmail.com
俄罗斯联邦, Moscow, 119991; Moscow, 119991