Role of Epithelial-Mesenchymal Transition in Tumor Progression


Цитировать

Полный текст

Открытый доступ Открытый доступ
Доступ закрыт Доступ предоставлен
Доступ закрыт Только для подписчиков

Аннотация

Epithelial–mesenchymal transition (EMT) is a fundamental process of morphogenesis whereby epithelial cells acquire the mesenchymal phenotype. Multiple data suggest a critical role of EMT in tumor progression. In carcinomas, EMT can be initiated and promoted by many oncogenic signaling pathways, hypoxia, and signals of tumor microenvironment resulting in epithelial cells losing their cell polarity and cell–cell adhesion and gaining the migratory and invasive properties. Downregulation of expression of the cell adhesion protein E–cadherin is considered a poor prognostic factor in cancer. Many tumors are characterized by incomplete EMT, where tumor cells acquire mesenchymal characteristics but retain their epithelial markers, in particular, E–cadherin. In cells with the hybrid epithelial–mesenchymal phenotype, E–cadherin is accumulated in adherens junctions which are less stable than adherens junctions in normal epithelial cells. E–cadherin–based adherens junctions are essential for efficient collective migration and invasion of carcinoma cells, and their survival in metastases. The plasticity of the hybrid epithelial–mesenchymal phenotype improves adaptive capabilities of cancer cells. By undergoing EMT, carcinoma cells become resistant to chemotherapy and acquire the ability to suppress immune response. Emergence of cancer stem cells after EMT activation has been observed in many types of carcinoma.

Об авторах

N. Gloushankova

Blokhin National Medical Research Center of Oncology

Автор, ответственный за переписку.
Email: natglu@hotmail.com
Россия, Moscow, 115478

I. Zhitnyak

Blokhin National Medical Research Center of Oncology

Email: natglu@hotmail.com
Россия, Moscow, 115478

S. Rubtsova

Blokhin National Medical Research Center of Oncology

Email: natglu@hotmail.com
Россия, Moscow, 115478

Дополнительные файлы

Доп. файлы
Действие
1. JATS XML

© Pleiades Publishing, Inc., 2018

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).