Mechanisms of non-canonical activation of ataxia telangiectasia mutated
- Авторы: Khoronenkova S.1,2
-
Учреждения:
- Department of Biochemistry
- Department of Chemistry
- Выпуск: Том 81, № 13 (2016)
- Страницы: 1669-1675
- Раздел: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151182
- DOI: https://doi.org/10.1134/S0006297916130058
- ID: 151182
Цитировать
Аннотация
ATM is a master regulator of the cellular response to DNA damage. The classical mechanism of ATM activation involves its monomerization in response to DNA double-strand breaks, resulting in ATM-dependent phosphorylation of more than a thousand substrates required for cell cycle progression, DNA repair, and apoptosis. Here, new experimental evidence for non-canonical mechanisms of ATM activation in response to stimuli distinct from DNA double-strand breaks is discussed. It includes cytoskeletal changes, chromatin modifications, RNA–DNA hybrids, and DNA single-strand breaks. Noncanonical ATM activation may be important for the pathology of the multisystemic disease Ataxia Telangiectasia.
Ключевые слова
Об авторах
S. Khoronenkova
Department of Biochemistry; Department of Chemistry
Автор, ответственный за переписку.
Email: sk870@cam.ac.uk
Великобритания, Cambridge, CB2 1GA; Moscow, 119991
![](/img/style/loading.gif)