AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites
- Авторы: Dyrkheeva N.1, Lebedeva N.1,2, Lavrik O.1,2,3
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Учреждения:
- Institute of Chemical Biology and Fundamental Medicine
- Novosibirsk State University
- Altai State University
- Выпуск: Том 81, № 9 (2016)
- Страницы: 951-967
- Раздел: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150999
- DOI: https://doi.org/10.1134/S0006297916090042
- ID: 150999
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Аннотация
Human apurinic/apyrimidinic endonuclease 1 (APE1) is one of the key participants in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5′-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3′-hydroxyl group and a 5′-deoxyribose phosphate moiety. APE1 exhibits 3′-phosphodiesterase, 3′-5′-exonuclease, and 3-phosphatase activities. APE1 was also identified as a redox factor (Ref-1). In this review, data on the role of APE1 in the DNA repair process and in other metabolic processes occurring in cells are analyzed as well as the interaction of this enzyme with DNA and other proteins participating in the repair system.
Об авторах
N. Dyrkheeva
Institute of Chemical Biology and Fundamental Medicine
Email: lavrik@niboch.nsc.ru
Россия, Novosibirsk, 630090
N. Lebedeva
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University
Email: lavrik@niboch.nsc.ru
Россия, Novosibirsk, 630090; Novosibirsk, 630090
O. Lavrik
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University; Altai State University
Автор, ответственный за переписку.
Email: lavrik@niboch.nsc.ru
Россия, Novosibirsk, 630090; Novosibirsk, 630090; Barnaul, 656049