Enviar artigo por via de e-mail Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes
- Autores: Sall F.1,2,3, Germini D.1,2, Kovina A.1,2,4, Ribrag V.5,6, Wiels J.1,2, Toure A.3, Iarovaia O.2,4, Lipinski M.1,2, Vassetzky Y.1,2,7
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Afiliações:
- UMR8126, Université Paris-Sud, CNRS
- LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”
- Laboratoire d’Hématologie Centre Hospitalier Universitaire Aristide Le Dantec
- Institute of Gene Biology
- Institut Gustave Roussy
- Institut National de la Santé et de la Recherche Médicale (INSERM) Unité (U) 1009, Université Paris Sud
- Koltzov Institute of Developmental Biology
- Edição: Volume 83, Nº 4 (2018)
- Páginas: 402-410
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151635
- DOI: https://doi.org/10.1134/S0006297918040119
- ID: 151635
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Resumo
Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein–Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.
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Sobre autores
F. Sall
UMR8126, Université Paris-Sud, CNRS; LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”; Laboratoire d’Hématologie Centre Hospitalier Universitaire Aristide Le Dantec
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805; Dakar
D. Germini
UMR8126, Université Paris-Sud, CNRS; LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805
A. Kovina
UMR8126, Université Paris-Sud, CNRS; LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”; Institute of Gene Biology
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805; Moscow, 119334
V. Ribrag
Institut Gustave Roussy; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité (U) 1009, Université Paris Sud
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805
J. Wiels
UMR8126, Université Paris-Sud, CNRS; LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805
A. Toure
Laboratoire d’Hématologie Centre Hospitalier Universitaire Aristide Le Dantec
Email: vassetzky@igr.fr
Senegal, Dakar
O. Iarovaia
LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”; Institute of Gene Biology
Email: vassetzky@igr.fr
França, Villejuif, 94805; Moscow, 119334
M. Lipinski
UMR8126, Université Paris-Sud, CNRS; LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805
Y. Vassetzky
UMR8126, Université Paris-Sud, CNRS; LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”; Koltzov Institute of Developmental Biology
Autor responsável pela correspondência
Email: vassetzky@igr.fr
França, Villejuif, 94805; Villejuif, 94805; Moscow, 119334
