Control of myofibroblast differentiation and function by cytoskeletal signaling
- Autores: Sandbo N.1, Smolyaninova L.2, Orlov S.2,3, Dulin N.3,4
-
Afiliações:
- University of Wisconsin, Department of Medicine
- Lomonosov Moscow State University, Faculty of Biology, Laboratory of Biomembranes
- Siberian State Medical University
- University of Chicago, Department of Medicine
- Edição: Volume 81, Nº 13 (2016)
- Páginas: 1698-1708
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151189
- DOI: https://doi.org/10.1134/S0006297916130071
- ID: 151189
Citar
Resumo
The cytoskeleton consists of three distinct types of protein polymer structures–microfilaments, intermediate filaments, and microtubules; each serves distinct roles in controlling cell shape, division, contraction, migration, and other processes. In addition to mechanical functions, the cytoskeleton accepts signals from outside the cell and triggers additional signals to extracellular matrix, thus playing a key role in signal transduction from extracellular stimuli through dynamic recruitment of diverse intermediates of the intracellular signaling machinery. This review summarizes current knowledge about the role of cytoskeleton in the signaling mechanism of fibroblast-to-myofibroblast differentiation–a process characterized by accumulation of contractile proteins and secretion of extracellular matrix proteins, and being critical for normal wound healing in response to tissue injury as well as for aberrant tissue remodeling in fibrotic disorders. Specifically, we discuss control of serum response factor and Hippo signaling pathways by actin and microtubule dynamics as well as regulation of collagen synthesis by intermediate filaments.
Sobre autores
N. Sandbo
University of Wisconsin, Department of Medicine
Email: ndulin@medicine.bsd.uchicago.edu
Estados Unidos da América, Madison, WI
L. Smolyaninova
Lomonosov Moscow State University, Faculty of Biology, Laboratory of Biomembranes
Email: ndulin@medicine.bsd.uchicago.edu
Rússia, Moscow, 119991
S. Orlov
Lomonosov Moscow State University, Faculty of Biology, Laboratory of Biomembranes; Siberian State Medical University
Autor responsável pela correspondência
Email: sergeinorlov@yandex.ru
Rússia, Moscow, 119991; Tomsk, 634050
N. Dulin
Siberian State Medical University; University of Chicago, Department of Medicine
Autor responsável pela correspondência
Email: ndulin@medicine.bsd.uchicago.edu
Rússia, Tomsk, 634050; Madison, IL, 5841