Enviar artigo por via de e-mail Alterations in tear biochemistry associated with postanesthetic chronic dry eye syndrome
- Autores: Zernii E.Y.1, Golovastova M.O.1, Baksheeva V.E.1, Kabanova E.I.2, Ishutina I.E.2, Gancharova O.S.1,3, Gusev A.E.4, Savchenko M.S.1, Loboda A.P.1, Sotnikova L.F.2, Zamyatnin A.A.1,5, Philippov P.P.1, Senin I.I.1
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Afiliações:
- Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
- Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Department of Biology and Pathology of Domestic, Laboratory and Exotic Animals
- Lomonosov Moscow State University, Institute of Mitoengineering, Pathology Department
- Principle Clinical Military Hospital of the Russian Federation
- Sechenov First Moscow State Medical University, Institute of Molecular Medicine
- Edição: Volume 81, Nº 12 (2016)
- Páginas: 1549-1557
- Seção: Regular Papers
- URL: https://journals.rcsi.science/0006-2979/article/view/151166
- DOI: https://doi.org/10.1134/S0006297916120166
- ID: 151166
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Resumo
Perioperative dry eye syndrome (DES) is a common ocular complication of long-term general anesthesia. Chronic DES can lead to permanent damage to the cornea and disturbance of visual function, up to total loss of vision. Here, a relationship between the duration of general anesthesia and the risk of chronic DES in patients was demonstrated. Using an experimental model of perioperative corneal abrasions in rabbits, it was found that introduction of animals to 3-h general anesthesia resulted in clinically significant chronic damage to the cornea in 50% of cases. The development of the complication was not associated with irreversible or long-term impairment of tear secretion, but it was accompanied by a decrease in tear film stability and growth of the total protein content as well as decrease in total antioxidant activity of the tear induced by low molecular weight antioxidants. In addition, anesthesia-induced changes in activity of tear antioxidant enzymes including superoxide dismutase and enzymes providing homeostasis of reduced glutathione (glutathione peroxidase, glutathione-S-transferase, glutathione reductase) were observed. All these alterations were protracted (up to 1-2 weeks) and therefore might account for transition of the perioperative DES into the chronic form. These findings can be useful in the development of novel approaches for the prevention and treatment of chronic forms of DES in the postanesthetic period.
Sobre autores
E. Zernii
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Autor responsável pela correspondência
Email: zerni@belozersky.msu.ru
Rússia, Moscow, 119991
M. Golovastova
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991
V. Baksheeva
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991
E. Kabanova
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Department of Biology and Pathology of Domestic, Laboratory and Exotic Animals
Email: senin@belozersky.msu.ru
Rússia, Moscow, 109472
I. Ishutina
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Department of Biology and Pathology of Domestic, Laboratory and Exotic Animals
Email: senin@belozersky.msu.ru
Rússia, Moscow, 109472
O. Gancharova
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Institute of Mitoengineering, Pathology Department
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991; Moscow, 119991
A. Gusev
Principle Clinical Military Hospital of the Russian Federation
Email: senin@belozersky.msu.ru
Rússia, Golitsyno, Moscow Region, 143040
M. Savchenko
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991
A. Loboda
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991
L. Sotnikova
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Department of Biology and Pathology of Domestic, Laboratory and Exotic Animals
Email: senin@belozersky.msu.ru
Rússia, Moscow, 109472
A. Zamyatnin
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology; Sechenov First Moscow State Medical University, Institute of Molecular Medicine
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991; Moscow, 119991
P. Philippov
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991
I. Senin
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Autor responsável pela correspondência
Email: senin@belozersky.msu.ru
Rússia, Moscow, 119991
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