Anti-amyloid Therapy of Alzheimer’s Disease: Current State and Prospects
- Авторлар: Kozin S.1, Barykin E.1, Mitkevich V.1, Makarov A.1
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Мекемелер:
- Engelhardt Institute of Molecular Biology
- Шығарылым: Том 83, № 9 (2018)
- Беттер: 1057-1067
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151713
- DOI: https://doi.org/10.1134/S0006297918090079
- ID: 151713
Дәйексөз келтіру
Аннотация
Drug development for the treatment of Alzheimer’s disease (AD) has been for a long time focused on agents that were expected to support endogenous β-amyloid (Aβ) in a monomeric state and destroy soluble Aβ oligomers and insoluble Aβ aggregates. However, this strategy has failed over the last 20 years and was eventually abandoned. In this review, we propose a new approach to the anti-amyloid AD therapy based on the latest achievements in understanding molecular causes of cerebral amyloidosis in AD animal models.
Негізгі сөздер
Авторлар туралы
S. Kozin
Engelhardt Institute of Molecular Biology
Email: mitkevich@gmail.com
Ресей, Moscow, 119991
E. Barykin
Engelhardt Institute of Molecular Biology
Email: mitkevich@gmail.com
Ресей, Moscow, 119991
V. Mitkevich
Engelhardt Institute of Molecular Biology
Хат алмасуға жауапты Автор.
Email: mitkevich@gmail.com
Ресей, Moscow, 119991
A. Makarov
Engelhardt Institute of Molecular Biology
Email: mitkevich@gmail.com
Ресей, Moscow, 119991