How fucose of blood group glycotypes programs human gut microbiota
- Авторлар: Kononova S.1
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Мекемелер:
- Institute of Protein Research
- Шығарылым: Том 82, № 9 (2017)
- Беттер: 973-989
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151462
- DOI: https://doi.org/10.1134/S0006297917090012
- ID: 151462
Дәйексөз келтіру
Аннотация
Formation of appropriate gut microbiota is essential for human health. The first two years of life is the critical period for this process. Selection of mutualistic microorganisms of the intestinal microbiota is controlled by the FUT2 and FUT3 genes that encode fucosyltransferases, enzymes responsible for the synthesis of fucosylated glycan structures of mucins and milk oligosaccharides. In this review, the mechanisms of the selection and maintenance of intestinal microorganisms that involve fucosylated oligosaccharides of breast milk and mucins of the newborn’s intestine are described. Possible reasons for the use of fucose, and not sialic acid, as the major biological signal for the selection are also discussed.
Негізгі сөздер
Авторлар туралы
S. Kononova
Institute of Protein Research
Хат алмасуға жауапты Автор.
Email: skonon23@gmail.com
Ресей, Pushchino, Moscow Region, 142290