Toward gene therapy of hypertension: Experimental study on hypertensive ISIAH rats
- Авторлар: Repkova M.1,2, Levina A.1,2, Seryapina A.1,3, Shikina N.1,4, Bessudnova E.1,4, Zarytova V.1,2, Markel A.1,3
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Мекемелер:
- Novosibirsk State University
- Institute of Chemical Biology and Fundamental Medicine
- Institute of Cytology and Genetics
- Institute of Catalysis
- Шығарылым: Том 82, № 4 (2017)
- Беттер: 454-457
- Бөлім: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151336
- DOI: https://doi.org/10.1134/S000629791704006X
- ID: 151336
Дәйексөз келтіру
Аннотация
TiO2-based nanocomposites were prepared to deliver oligonucleotides into cells. The nanocomposites were designed by the immobilization of polylysine-containing oligonucleotides on TiO2-nanoparticles (TiO2·PL-DNA). We showed for the first time the possibility of using the proposed nanocomposites for treatment of hypertensive disease by introducing them into hypertensive ISIAH rats developed as a model of stress-sensitive arterial hypertension. The mRNA of the gene encoding angiotensin I-converting enzyme (ACE1) involved in the synthesis of angiotensin II was chosen as a target. Administration (intraperitoneal injection and inhalation) of the nanocomposite showed a significant (by 20-30 mm Hg) decrease in systolic blood pressure when the nanocomposite contained the ACE1 gene-targeted oligonucleotide. When using the oligonucleotide with a random sequence, no effect was observed. Further development and improvement of the inhalation nanocomposite drug delivery to systemic hypertensive disease treatment promises new possibilities for clinical practice.
Негізгі сөздер
Авторлар туралы
M. Repkova
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
A. Levina
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
A. Seryapina
Novosibirsk State University; Institute of Cytology and Genetics
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
N. Shikina
Novosibirsk State University; Institute of Catalysis
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
E. Bessudnova
Novosibirsk State University; Institute of Catalysis
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
V. Zarytova
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
A. Markel
Novosibirsk State University; Institute of Cytology and Genetics
Хат алмасуға жауапты Автор.
Email: markel@bionet.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090