Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery
- Авторлар: Dolinnaya N.1, Ogloblina A.2, Yakubovskaya M.2
-
Мекемелер:
- Department of Chemistry
- Blokhin Cancer Research Center, Institute of Carcinogenesis
- Шығарылым: Том 81, № 13 (2016)
- Беттер: 1602-1649
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151177
- DOI: https://doi.org/10.1134/S0006297916130034
- ID: 151177
Дәйексөз келтіру
Аннотация
G-quadruplexes (G4s), which are known to have important roles in regulation of key biological processes in both normal and pathological cells, are the most actively studied non-canonical structures of nucleic acids. In this review, we summarize the results of studies published in recent years that change significantly scientific views on various aspects of our understanding of quadruplexes. Modern notions on the polymorphism of DNA quadruplexes, on factors affecting thermodynamics and kinetics of G4 folding–unfolding, on structural organization of multiquadruplex systems, and on conformational features of RNA G4s and hybrid DNA–RNA G4s are discussed. Here we report the data on location of G4 sequence motifs in the genomes of eukaryotes, bacteria, and viruses, characterize G4-specific small-molecule ligands and proteins, as well as the mechanisms of their interactions with quadruplexes. New information on the structure and stability of G4s in telomeric DNA and oncogene promoters is discussed as well as proof being provided on the occurrence of G-quadruplexes in cells. Prominence is given to novel experimental techniques (single molecule manipulations, optical and magnetic tweezers, original chemical approaches, G4 detection in situ, in-cell NMR spectroscopy) that facilitate breakthroughs in the investigation of the structure and functions of G-quadruplexes.
Авторлар туралы
N. Dolinnaya
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: dolinnaya@hotmail.com
Ресей, Moscow, 119991
A. Ogloblina
Blokhin Cancer Research Center, Institute of Carcinogenesis
Email: dolinnaya@hotmail.com
Ресей, Moscow, 115478
M. Yakubovskaya
Blokhin Cancer Research Center, Institute of Carcinogenesis
Email: dolinnaya@hotmail.com
Ресей, Moscow, 115478
![](/img/style/loading.gif)