Role of ceramide in apoptosis and development of insulin resistance
- Авторлар: Kuzmenko D.1, Klimentyeva T.1
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Мекемелер:
- Siberian State Medical University
- Шығарылым: Том 81, № 9 (2016)
- Беттер: 913-927
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150993
- DOI: https://doi.org/10.1134/S0006297916090017
- ID: 150993
Дәйексөз келтіру
Аннотация
This review presents data on the functional biochemistry of ceramide, one of the key sphingolipids with properties of a secondary messenger. Molecular mechanisms of the involvement of ceramide in apoptosis in pancreatic β-cells and its role in the formation of insulin resistance in pathogenesis of type 2 diabetes are reviewed. One of the main predispositions for the development of insulin resistance and diabetes is obesity, which is associated with ectopic fat deposition and significant increase in intracellular concentrations of cytotoxic ceramides. A possible approach to the restoration of tissue sensitivity to insulin in type 2 diabetes based on selective reduction of the content of cytotoxic ceramides is discussed.
Негізгі сөздер
Авторлар туралы
D. Kuzmenko
Siberian State Medical University
Хат алмасуға жауапты Автор.
Email: dik51@mail.ru
Ресей, Tomsk, 634050
T. Klimentyeva
Siberian State Medical University
Email: dik51@mail.ru
Ресей, Tomsk, 634050
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