Enhancement of Declarative Memory: From Genetic Regulation to Non-invasive Stimulation
- Authors: Bryzgalov D.V.1, Kuznetsova I.L.2, Rogaev E.I.2,3,4,5
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Affiliations:
- Memory, Oscillations, Brain States (MOBS) Team, Brain Plasticity Unit
- Vavilov Institute of General Genetics
- Department of Psychiatry
- Faculty of Biology
- Faculty of Bioengineering and Bioinformatics
- Issue: Vol 83, No 9 (2018)
- Pages: 1124-1138
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151725
- DOI: https://doi.org/10.1134/S0006297918090146
- ID: 151725
Cite item
Abstract
The problem of memory enhancement is extremely important in intellectual activity areas and therapy of different types of dementia, including Alzheimer’s disease (AD). The attempts to solve this problem have come from different research fields. In the first part of our review, we describe the results of targeting certain genes involved in memory-associated molecular pathways. The second part of the review is focused on the deep stimulation of brain structures that can slow down memory loss in AD. The third part describes the results of the use of non-invasive brain stimulation techniques for memory modulation, consolidation, and retrieval in healthy people and animal models. Integration of data from different research fields is essential for the development of efficient strategies for memory enhancement.
Keywords
About the authors
D. V. Bryzgalov
Memory, Oscillations, Brain States (MOBS) Team, Brain Plasticity Unit
Author for correspondence.
Email: bryzgalovdm@gmail.com
France, Paris
I. L. Kuznetsova
Vavilov Institute of General Genetics
Email: rogaev@vigg.ru
Russian Federation, Moscow, 119991
E. I. Rogaev
Vavilov Institute of General Genetics; Department of Psychiatry; Faculty of Biology; Faculty of Bioengineering and Bioinformatics
Author for correspondence.
Email: rogaev@vigg.ru
Russian Federation, Moscow, 119991; Worcester, MA, 01605; Moscow, 119234; Moscow, 119234